Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?
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منابع مشابه
Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?
BACKGROUND Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated dialysate water. METHODS HD patients only treated with Reverse Osmosis(RO) tr...
متن کاملDoes oral aluminium cause toxicity? Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels?
Background We wished to determine the risk of Al toxicity in HD patients receiving Alucaps but never exposed to contaminated dialysate water. Methods HD patients only treated with Reverse Osmosis(RO) treated dialysis water with either current or past exposure to Alucaps were given standardised DFO tests. Post-DFO serum Al level >3.0μmol/L was defined to indicate toxic loads based on previous bo...
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BACKGROUND Aluminium-containing phosphate binders have long been used for treatment of hyperphosphatemia in dialysis patients. Their safety became controversial in the early 1980's after reports of aluminium related neurological and bone disease began to appear. Available historical evidence however, suggests that neurological toxicity may have primarily been caused by excessive exposure to alu...
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Using atomic absorption spectrometry the aluminium concentrations in blood and urine and in two iliac bone biopsies obtained from welders with long term exposure to fumes containing aluminium were measured. The urinary excretion of two workers who had welded for 20 and 21 years varied between 107 and 351 micrograms Al/l, more than 10 times the concentration found in persons without occupational...
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A summary of the information available on the incidence of toxic quantities of exchangeable aluminium in sandy soils is presented. Attention is focused on the widespread nature of this condition.
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ژورنال
عنوان ژورنال: BMC Nephrology
سال: 2011
ISSN: 1471-2369
DOI: 10.1186/1471-2369-12-55